Navidea Biopharmaceuticals Appoints Dr. Michael Rosol as Chief Medical Officer

DUBLIN, Ohio–(BUSINESS WIRE)–Navidea Biopharmaceuticals, Inc. (NYSE American: NAVB) (“Navidea” or the
“Company”), a company focused on the development of precision
immunodiagnostic agents and immunotherapeutics, today announced the
appointment of Michael Rosol, PhD as Chief Medical Officer of Navidea,
effective December 17, 2018. Dr. Rosol brings to this position over 10
years of experience in biomedical imaging and commercialization.

“We are pleased for Dr. Rosol to join Navidea and bring his deep
insights into the needs of the industry for the development, validation
and implementation of imaging biomarkers in clinical trials,” said
Mr. Jed A. Latkin, Chief Executive Officer of Navidea. “He brings a
wealth of knowledge and extensive experience to Navidea as we move
forward with advancing our novel pipeline of imaging products and
bringing products to market.”

“I am excited to join Navidea as Chief Medical Officer at a key stage in
the advancement of Navidea’s business,” commented Dr. Rosol. “I look
forward to working with the leadership team to develop innovative
immunodiagnostic agents and immunotherapeutics that can meaningfully
improve the lives of patients living with devastating conditions.”

Prior to joining Navidea, Dr. Rosol served as Associate Director in the
Clinical and Translational Imaging Group at Novartis Institutes for
BioMedical Research from November 2016 to December 2018. Before that, he
held positions as Senior Director of Business Development at Elucid
Bioimaging, Inc. where he drove adoption of its Computer-Aided
Phenotyping applications from May 2016 to November 2016, and as Chief
Scientific Officer of MediLumine, Inc. from October 2015 to May 2016.
Prior to those roles, he was the Head of the Translational Imaging Group
at Novartis Pharmaceuticals Group from October 2012 to March 2015. His
training and experience lie in the fields of biophysics, physiology, and
biological/medical imaging, and his work has focused on cardiovascular
imaging, preclinical and clinical imaging instrumentation and
applications, animal models of human disease, pathophysiology,
biomarkers, and imaging in toxicological and clinical trials. He has
also served as faculty in Radiology and Director of two academic
research imaging facilities. Dr. Rosol holds a PhD from Boston
University School of Medicine.

About Navidea

Navidea Biopharmaceuticals, Inc. (NYSE American: NAVB) is a
biopharmaceutical company focused on the development of precision
immunodiagnostic agents and immunotherapeutics. Navidea is developing
multiple precision-targeted products based on its Manocept™ platform to
enhance patient care by identifying the sites and pathways of disease
and enable better diagnostic accuracy, clinical decision-making, and
targeted treatment. Navidea’s Manocept platform is predicated on the
ability to specifically target the CD206 mannose receptor expressed on
activated macrophages. The Manocept platform serves as the molecular
backbone of Tc99m tilmanocept, the first product developed and
commercialized by Navidea based on the platform. The development
activities of the Manocept immunotherapeutic platform are being
conducted by Navidea in conjunction with its subsidiary, Macrophage
Therapeutics, Inc. Navidea’s strategy is to deliver superior growth and
shareholder return by bringing to market novel products and advancing
the Company’s pipeline through global partnering and commercialization
efforts.

For more information, please visit www.navidea.com.

Forward-Looking Statements

This release and any oral statements made with respect to the
information contained in this release contains forward-looking
statements within the meaning of Section 27A of the Securities Act of
1933, as amended, and Section 21E of the Securities Exchange Act of
1934, as amended. We have based these forward-looking statements largely
on our current expectations and projections about future events and
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These forward-looking statements are subject to a number of risks,
uncertainties and assumptions, including, among other things: any future
actions by Platinum-Montaur; general economic and business conditions,
both nationally and in our markets; our history of losses and
uncertainty of future profitability; the final outcome of the CRG
litigation in Texas and Ohio; our ability to successfully complete
research and further development of our drug candidates; the timing,
cost and uncertainty of obtaining regulatory approvals of our drug
candidates; our ability to successfully commercialize our drug
candidates; our expectations and estimates concerning future financial
performance, financing plans and the impact of competition; our ability
to raise capital sufficient to fund our development and
commercialization programs; our ability to implement our growth
strategy; anticipated trends in our business; advances in technologies;
our ability to comply with the NYSE American continued listing
standards; and other risk factors detailed in our most recent Annual
Report on Form 10-K and other SEC filings. You are urged to carefully
review and consider the disclosures found in our SEC filings, which are
available at www.sec.gov or
at http://ir.navidea.com.

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